Global proportion of cancer cases attributable to selected modifiable risk factors and exposure trends for cancers

Quantified mortality drivers:

Tobacco

Smoking

Second-hand smoke

Dietary

Diet in high sodium

Low calcium intake

Low fruit & vegetable intake

Metabolic

Physical inactivity

Hyperglycemia & diabetes

Obesity

Alcohol

Alcohol

Air pollution

Air pollution

Occupational carcinogens

Occupational carcinogens

Qualitative assessment of other drivers:

Infection

Hepatitis B virus (HBV)

Hepatitis C virus (HCV)

Helicobacter pylori (HP)

Human papilloma virus (HPV)

Epstein Barr virus (EBV)

Reproductive

Breastfeeding

Nulliparity

Early age of Menarche

Exposure trends:

Note: These proportion estimates are not adjusted for co-exposure of multiple risk factors.
Source: Swiss Re; GBD 2019 Cancer Risk Factors Collaborators, 'The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019', Lancet, 2022.